https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACytochrome_P450%2F33%2Fen 2026-09-14T15:56:55Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Cytochrome_P450/33/en&diff=129058&oldid=prev 2024-03-15T11:35:29Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>The classes of P450s most often investigated in non-human animals are those either involved in [[developmental biology|development]] (e.g., [[retinoic acid]] or [[hormone]] metabolism) or involved in the metabolism of toxic compounds (such as [[heterocyclic amine]]s or [[polyaromatic hydrocarbons]]). Often there are differences in [[gene regulation]] or [[enzyme function]] of P450s in related animals that explain observed differences in susceptibility to toxic compounds (ex. canines&#039; inability to metabolize xanthines such as caffeine). Some drugs undergo metabolism in both species via different enzymes, resulting in different metabolites, while other drugs are metabolized in one species but excreted unchanged in another species. For this reason, one species&#039;s reaction to a substance is not a reliable indication of the substance&#039;s effects in humans. A species of Sonoran Desert Drosophila that uses an upregulated expression of the [[CYP28A1]] gene for detoxification of cacti rot is &#039;&#039;[[Drosophila mettleri]]&#039;&#039;. Flies of this species have adapted an upregulation of this gene due to exposure of high levels of alkaloids in host plants.</div>

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