https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACytochrome_P450%2F27%2Fen 2026-08-21T05:36:14Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Cytochrome_P450/27/en&diff=129052&oldid=prev 2024-03-15T11:35:29Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>====Steroid hormones====<br /> [[File:Steroidogenesis.svg|thumb|400px|[[Steroidogenesis]], showing many of the enzyme activities that are performed by cytochrome P450 enzymes. HSD: Hydroxysteroid dehydrogenase.]]<br /> A subset of cytochrome P450 enzymes play important roles in the synthesis of [[steroid hormone]]s ([[steroidogenesis]]) by the [[adrenal gland|adrenal]]s, [[gonad]]s, and peripheral tissue:<br /> * [[CYP11A1]] (also known as P450scc or P450c11a1) in adrenal [[mitochondrion|mitochondria]] affects &quot;the activity formerly known as 20,22-desmolase&quot; (steroid 20α-hydroxylase, steroid 22-hydroxylase, cholesterol [[Side chain|side-chain]] scission).<br /> * [[CYP11B1]] (encoding the protein P450c11β) found in the [[inner mitochondrial membrane]] of [[adrenal cortex]] has steroid 11β-hydroxylase, steroid [[18-hydroxylase]], and steroid 18-methyloxidase activities.<br /> * [[CYP11B2]] (encoding the protein P450c11AS), found only in the mitochondria of the adrenal [[zona glomerulosa]], has steroid 11β-hydroxylase, steroid 18-hydroxylase, and steroid 18-methyloxidase activities.<br /> * [[CYP17A1]], in endoplasmic reticulum of adrenal cortex has steroid 17α-hydroxylase and 17,20-lyase activities.<br /> * [[CYP21A2]] (P450c21) in adrenal cortex conducts [[21-hydroxylase]] activity.<br /> * [[CYP19A]] (P450arom, [[aromatase]]) in [[endoplasmic reticulum]] of [[gonads]], [[brain]], [[adipose tissue]], and elsewhere catalyzes [[aromatization]] of [[androgens]] to [[estrogens]].</div>

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