https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACytochrome_P450%2F20%2FenTranslations:Cytochrome P450/20/en - Revision history2026-11-12T07:22:12ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Cytochrome_P450/20/en&diff=129045&oldid=prevFuzzyBot: Importing a new version from external source2024-03-15T11:35:29Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>Effects on P450 isozyme activity are a major source of adverse [[drug interaction]]s, since changes in P450 enzyme activity may affect the [[drug metabolism|metabolism]] and [[medical clearance|clearance]] of various drugs. For example, if one drug inhibits the P450-mediated metabolism of another drug, the second drug may accumulate within the body to toxic levels. Hence, these drug interactions may necessitate dosage adjustments or choosing drugs that do not interact with the P450 system. Such drug interactions are especially important to consider when using drugs of vital importance to the patient, drugs with significant [[adverse effect|side-effects]], or drugs with a narrow [[therapeutic index]], but any drug may be subject to an altered plasma concentration due to altered drug metabolism.</div>FuzzyBot