https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACytochrome_P450%2F14%2Fen 2026-07-10T03:25:45Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Cytochrome_P450/14/en&diff=129039&oldid=prev 2024-03-15T11:35:28Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>==P450s in humans==<br /> Human P450s are primarily membrane-associated proteins located either in the inner membrane of [[mitochondria]] or in the [[endoplasmic reticulum]] of cells. P450s metabolize thousands of [[endogenous]] and [[exogenous]] chemicals. Some P450s metabolize only one (or a very few) substrates, such as &#039;&#039;CYP19&#039;&#039; ([[aromatase]]), while others may metabolize multiple [[Substrate (biochemistry)|substrates]]. Both of these characteristics account for their central importance in [[medicine]]. Cytochrome P450 enzymes are present in most tissues of the body, and play important roles in [[hormone]] synthesis and breakdown (including [[estrogen]] and [[testosterone]] synthesis and metabolism), [[cholesterol]] synthesis, and [[vitamin D]] metabolism. Cytochrome P450 enzymes also function to metabolize potentially toxic compounds, including [[drugs]] and products of endogenous metabolism such as [[bilirubin]], principally in the [[liver]].</div>

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