https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACollagen%2F23%2FenTranslations:Collagen/23/en - Revision history2026-05-08T21:42:06ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Collagen/23/en&diff=143109&oldid=prevFuzzyBot: Importing a new version from external source2024-04-22T13:55:39Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div># Inside the cell<br />
## Two types of alpha chains – alpha-1 and alpha 2, are formed during [[translation (genetics)|translation]] on ribosomes along the [[rough endoplasmic reticulum]] (RER). These peptide chains known as preprocollagen, have registration peptides on each end and a [[signal peptide]].<br />
## Polypeptide chains are released into the lumen of the RER.<br />
## Signal peptides are cleaved inside the RER and the chains are now known as pro-alpha chains.<br />
## [[Hydroxylation]] of [[lysine]] and [[proline]] amino acids occurs inside the lumen. This process is dependent on and consumes [[ascorbic acid]] (vitamin C) as a [[cofactor (biochemistry)|cofactor]].<br />
## [[Glycosylation]] of specific hydroxylysine residues occurs.<br />
## Triple alpha helical structure is formed inside the endoplasmic reticulum from two alpha-1 chains and one alpha-2 chain.<br />
## [[Procollagen]] is shipped to the [[Golgi apparatus]], where it is packaged and secreted into extracellular space by [[exocytosis]].<br />
# Outside the cell<br />
## Registration peptides are cleaved and tropocollagen is formed by [[procollagen peptidase]].<br />
## Multiple tropocollagen molecules form collagen fibrils, via covalent cross-linking ([[aldol reaction]]) by [[lysyl oxidase]] which links hydroxylysine and lysine residues. Multiple collagen fibrils form into collagen fibers.<br />
## Collagen may be attached to cell membranes via several types of protein, including [[fibronectin]], [[laminin]], [[fibulin]] and [[integrin]].</div>FuzzyBot