https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACitric_acid_cycle%2F42%2Fen 2026-08-25T02:34:56Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Citric_acid_cycle/42/en&diff=132141&oldid=prev 2024-03-31T02:38:40Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>Several of the citric acid cycle intermediates are used for the synthesis of important compounds, which will have significant cataplerotic effects on the cycle.<br /> &#039;&#039;Acetyl-CoA&#039;&#039; cannot be transported out of the mitochondrion. To obtain cytosolic acetyl-CoA, &#039;&#039;citrate&#039;&#039; is removed from the citric acid cycle and carried across the inner mitochondrial membrane into the cytosol. There it is cleaved by [[ATP citrate lyase]] into acetyl-CoA and oxaloacetate. The oxaloacetate is returned to mitochondrion as &#039;&#039;malate&#039;&#039; (and then converted back into &#039;&#039;oxaloacetate&#039;&#039; to transfer more &#039;&#039;acetyl-CoA&#039;&#039; out of the mitochondrion). The cytosolic acetyl-CoA is used for [[fatty acid synthesis]] and the [[Mevalonate pathway|production of cholesterol]]. [[Cholesterol]] can, in turn, be used to synthesize the [[Steroid#Steroidogenesis|steroid hormones]], [[Bile acids|bile salts]], and [[vitamin D]].</div>

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