https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACitric_acid_cycle%2F29%2FenTranslations:Citric acid cycle/29/en - Revision history2026-09-14T09:29:10ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Citric_acid_cycle/29/en&diff=132128&oldid=prevFuzzyBot: Importing a new version from external source2024-03-31T02:38:40Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>'''Transcriptional regulation'''. Recent work has demonstrated an important link between intermediates of the citric acid cycle and the regulation of [[hypoxia-inducible factors]] ([[HIF1A|HIF]]). HIF plays a role in the regulation of oxygen [[homeostasis]], and is a transcription factor that targets [[angiogenesis]], [[Vascular remodelling in the embryo|vascular remodeling]], [[glucose]] utilization, iron transport and [[apoptosis]]. HIF is synthesized constitutively, and [[hydroxylation]] of at least one of two critical [[proline]] residues mediates their interaction with the von Hippel Lindau [[E3 ubiquitin ligase]] complex, which targets them for rapid degradation. This reaction is catalysed by [[prolyl hydroxylase|prolyl 4-hydroxylases]]. Fumarate and succinate have been identified as potent inhibitors of prolyl hydroxylases, thus leading to the stabilisation of HIF.</div>FuzzyBot