https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACitric_acid_cycle%2F26%2Fen 2026-05-28T21:56:03Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Citric_acid_cycle/26/en&diff=132125&oldid=prev 2024-03-31T02:38:40Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>== Regulation ==<br /> &#039;&#039;&#039;Allosteric regulation by metabolites&#039;&#039;&#039;. The regulation of the citric acid cycle is largely determined by product inhibition and substrate availability. If the cycle were permitted to run unchecked, large amounts of [[Metabolism|metabolic]] energy could be wasted in overproduction of reduced coenzyme such as NADH and ATP. The major eventual substrate of the cycle is ADP which gets converted to ATP. A reduced amount of ADP causes accumulation of precursor NADH which in turn can inhibit a number of enzymes. NADH, a product of all dehydrogenases in the citric acid cycle with the exception of [[succinate dehydrogenase]], inhibits [[pyruvate dehydrogenase]], [[isocitrate dehydrogenase]], [[Alpha-ketoglutarate dehydrogenase|α-ketoglutarate dehydrogenase]], and also [[citrate synthase]]. [[Acetyl-coA]] inhibits [[pyruvate dehydrogenase]], while [[succinyl-CoA]] inhibits alpha-ketoglutarate dehydrogenase and [[citrate synthase]]. When tested in vitro with TCA enzymes, &#039;&#039;&#039;ATP&#039;&#039;&#039; inhibits [[citrate synthase]] and [[Alpha-ketoglutarate dehydrogenase|α-ketoglutarate dehydrogenase]]; however, ATP levels do not change more than 10% in vivo between rest and vigorous exercise. There is no known [[allosteric]] mechanism that can account for large changes in reaction rate from an allosteric effector whose concentration changes less than 10%.</div>

FuzzyBot