https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACitric_acid_cycle%2F20%2Fen 2026-10-09T07:18:16Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Citric_acid_cycle/20/en&diff=132119&oldid=prev 2024-03-31T02:38:40Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>== Efficiency ==<br /> The theoretical maximum yield of [[ATP synthase|ATP]] through oxidation of one molecule of glucose in glycolysis, citric acid cycle, and [[oxidative phosphorylation]] is 38 (assuming 3 [[molar equivalent]]s of ATP per equivalent NADH and 2 ATP per FADH&lt;sub&gt;2&lt;/sub&gt;). In eukaryotes, two equivalents of NADH and two equivalents of ATP are generated in [[glycolysis]], which takes place in the [[cytoplasm]]. If transported using the [[glycerol phosphate shuttle]] rather than the [[malate-aspartate shuttle]], transport of two of these equivalents of NADH into the mitochondria effectively consumes two equivalents of ATP, thus reducing the net production of ATP to 36. Furthermore, inefficiencies in [[oxidative phosphorylation]] due to leakage of protons across the [[Mitochondrion|mitochondrial membrane]] and slippage of the [[ATP synthase]]/proton pump commonly reduces the ATP yield from NADH and [[Flavin adenine dinucleotide|FADH&lt;sub&gt;2&lt;/sub&gt;]] to less than the theoretical maximum yield. The observed yields are, therefore, closer to ~2.5 ATP per NADH and ~1.5 ATP per FADH&lt;sub&gt;2&lt;/sub&gt;, further reducing the total net production of ATP to approximately 30. An assessment of the total ATP yield with newly revised proton-to-ATP ratios provides an estimate of 29.85 ATP per glucose molecule.</div>

FuzzyBot