https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACalcitroic_acid%2F2%2Fen 2026-05-11T16:30:41Z Revision history for this page on the wiki MediaWiki 1.43.0 https://wiki.tiffa.net/w/index.php?title=Translations:Calcitroic_acid/2/en&diff=138291&oldid=prev 2024-04-12T12:58:22Z

<p>Importing a new version from external source</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Calcitroic acid&#039;&#039;&#039; (1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D&lt;sub&gt;3&lt;/sub&gt;) is a major [[metabolite]] of [[calcitriol|1α,25-dihydroxyvitamin D&lt;sub&gt;3&lt;/sub&gt;]] (calcitriol). Around 1980, scientists first reported the isolation of calcitroic acid from the aqueous extract of radioactively treated animals&#039; livers and intestines. Subsequent researches confirmed calcitroic acid to be a part of [[enterohepatic circulation]]. Often synthesized in the liver and kidneys, calcitroic acid is generated in the body after [[vitamin D]] is first converted into calcitriol, an intermediate in the fortification of bone through the formation and regulation of calcium in the body. These pathways managed by calcitriol are thought to be inactivated through its hydroxylation by the [[enzyme]] [[CYP24A1]], also called calcitriol 24-hydroxylase.Specifically, It is thought to be the major route to inactivate vitamin D metabolites. The hydroxylation and oxidation reactions will yield either calcitroic acid via the C24 oxidation pathway or 1,25(OH2)D3-26,23-lactone via the C23 lactone pathway.</div>

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