https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ACalcifediol%2F3%2FenTranslations:Calcifediol/3/en - Revision history2026-10-17T09:58:07ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Calcifediol/3/en&diff=138107&oldid=prevFuzzyBot: Importing a new version from external source2024-04-12T11:39:27Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>==Biology==<br />
Calcifediol is the precursor for calcitriol, the active form of vitamin D. It is synthesized in the liver, by hydroxylation of cholecalciferol (vitamin D<sub>3</sub>) at the 25-position. This enzymatic 25-hydroxylase reaction is mostly due to the actions of [[CYP2R1]], present in [[microsomes]], although other enzymes such as [[mitochondrial]] [[CYP27A1]] can contribute. Variations in the expression and activity of CYP2R1, such as low levels in [[obesity]], affect circulating calcifediol. Similarly, vitamin D<sub>2</sub>, [[ergocalciferol]], can also be 25-hydroxylated to form 25-hydroxyergocalciferol, (ercalcidiol, 25(OH)D<sub>2</sub>); both forms are measured together in blood as 25(OH)D.</div>FuzzyBot