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==Interference with medical laboratory results==
When people are ingesting high levels of biotin in [[dietary supplement]]s, a consequence can be clinically significant interference with [[diagnosis|diagnostic]] blood tests that use biotin-streptavidin technology. This methodology is commonly used to measure levels of hormones such as [[thyroid hormones]], and other analytes such as 25-hydroxyvitamin D. Biotin interference can produce both falsely normal and falsely abnormal results. In the US, biotin as a non-prescription dietary supplement is sold in amounts of 1 to 10 mg per serving, with claims for supporting hair and nail health, and as 300 mg per day as a possibly effective treatment for multiple sclerosis (see [[Biotin#Research|§ Research]]). Overconsumption of 5 mg/day or higher causes elevated concentration in plasma that interferes with biotin-streptavidin immunoassays in an unpredictable manner. Healthcare professionals are advised to instruct patients to stop taking biotin supplements for 48 h or even up to weeks before the test, depending on the specific test, dose, and frequency of biotin uptake. Guidance for laboratory staff is proposed to detect and manage biotin interference.

Translations:Biotin/30/en - Revision history

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