https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3ABiguanide%2F17%2FenTranslations:Biguanide/17/en - Revision history2026-05-08T09:23:59ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Biguanide/17/en&diff=128186&oldid=prevFuzzyBot: Importing a new version from external source2024-03-12T08:13:01Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>===Antimalarial===<br />
During WWII a British team led by [[Frank Rose (chemist)|Frank Rose]] discovered (see details there) that some biguanides are useful as [[antimalarial drug]]s. Much later it was demonstrated that they are prodrugs metabolised into active [[dihydrotriazine]] derivatives which, until recently, were believed to work by [[Dihydrofolate reductase inhibitor|inhibiting]] [[dihydrofolate reductase]]. Examples include:<br />
* [[Proguanil]] (>[[cycloguanil]])<br />
* [[Chlorproguanil]]</div>FuzzyBot