https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AAtherosclerosis%2F79%2FenTranslations:Atherosclerosis/79/en - Revision history2026-09-15T04:19:29ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Atherosclerosis/79/en&diff=124945&oldid=prevFuzzyBot: Importing a new version from external source2024-03-05T13:10:03Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>=== Vascular smooth muscle cells ===<br />
[[Vascular smooth muscle|Vascular smooth muscle cells]] play a key role in atherogenesis and were historically considered to be beneficial for plaque stability by forming a protective fibrous cap and synthesising strength-giving [[extracellular matrix]] components. However, in addition to the fibrous cap, vascular smooth muscle cells also give rise to many of the cell types found within the plaque core and can modulate their phenotype to both promote and reduce plaque stability. Vascular smooth muscle cells exhibit pronounced plasticity within atherosclerotic plaque and can modify their gene expression profile to resemble various other cell types, including [[macrophage]]s, [[myofibroblast]]s, [[mesenchymal stem cell]]s and osteochondrocytes. Importantly, genetic lineage‐tracing experiments have unequivocally shown that 40-90% of plaque-resident cells are vascular smooth muscle cell derived, therefore, it is important to research the role of vascular smooth muscle cells in atherosclerosis to identify new therapeutic targets.</div>FuzzyBot