https://wiki.tiffa.net/w/index.php?action=history&feed=atom&title=Translations%3AAtherosclerosis%2F42%2FenTranslations:Atherosclerosis/42/en - Revision history2026-09-15T04:20:42ZRevision history for this page on the wikiMediaWiki 1.43.0https://wiki.tiffa.net/w/index.php?title=Translations:Atherosclerosis/42/en&diff=124908&oldid=prevFuzzyBot: Importing a new version from external source2024-03-05T13:10:03Z<p>Importing a new version from external source</p>
<p><b>New page</b></p><div>===Accelerated growth of plaques===<br />
The distribution of atherosclerotic plaques in a part of arterial endothelium is inhomogeneous. The multiple and focal development of atherosclerotic changes is similar to that in the development of [[amyloid plaques]] in the brain and that of age spots on the skin. Misrepair-accumulation aging theory suggests that misrepair mechanisms play an important role in the focal development of atherosclerosis. Development of a plaque is a result of repair of injured endothelium. Because of the infusion of lipids into sub-endothelium, the repair has to end up with altered remodeling of local endothelium. This is the manifestation of a misrepair. Important is this altered remodeling makes the local endothelium have increased fragility to damage and have reduced repair efficiency. As a consequence, this part of endothelium has an increased risk factor of being injured and improperly repaired. Thus, the accumulation of misrepairs of endothelium is focalized and self-accelerating. In this way, the growing of a plaque is also self-accelerating. Within a part of the arterial wall, the oldest plaque is always the biggest, and is the most dangerous one to cause blockage of a local artery.</div>FuzzyBot