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Atherogenesis is the developmental process of [[Atheroma|atheromatous plaques]]. It is characterized by a remodeling of arteries leading to subendothelial accumulation of fatty substances called plaques. The buildup of an atheromatous plaque is a slow process, developed over a period of several years through a complex series of cellular events occurring within the arterial wall and in response to a variety of local vascular circulating factors. One recent hypothesis suggests that, for unknown reasons, [[leukocytes]], such as [[monocytes]] or [[basophils]], begin to attack the [[endothelium]] of the artery lumen in [[cardiac muscle]]. The ensuing [[inflammation]] leads to the formation of atheromatous plaques in the arterial [[tunica intima]], a region of the vessel wall located between the [[endothelium]] and the [[tunica media]]. The bulk of these lesions is made of excess fat, [[collagen]], and [[elastin]]. At first, as the plaques grow, only [[intima-media thickness|wall thickening]] occurs without any narrowing. [[Stenosis]] is a late event, which may never occur and is often the result of repeated plaque rupture and healing responses, not just the atherosclerotic process by itself.

Translations:Atherosclerosis/23/en - Revision history

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