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*[[Adrenergic agonists]] that work on the [[beta-2 adrenergic receptor]] increase energy expenditure. Although some such as [[clenbuterol]] are used without medical approval for weight loss, none have achieved approval for this indication due to cardiac risks. The anti-obesity effects of [[amphetamines]], besides acting on the brain to reduce energy intake, are also mediated by the beta-2 adrenergic receptor. [[Ephedrine]] (and related compounds that are also active ingredients in [[Ephedra (medicine)|ephedra]] preparations) exert their effects by acting directly and indirectly as adrenergic agonists.
*The discontinued drug [[2,4-dinitrophenol]] works by increasing energy expenditure by decreasing the efficiency of mitochondria ([[uncoupling agent]]). A [[prodrug]] of DNP, [[HU6]], has been tested in clinical trials for weight loss and [[fatty liver disease]].
*[[FGF21|Fibroblast growth factor-21]] receptor agonists and drugs increasing FGF-21 activity are being investigated for obesity-related diseases; they can increase energy expenditure and several have been tested in humans.
*[[Thyroid hormone]]s, another early weight loss drug, also raised energy expenditure but ceased to be used for weight loss due to cardiac risks and other adverse effects. Selective [[thyromimetic]]s that work on the [[thyroid hormone receptor beta]] may be able to exert some of the beneficial [[thermogenic]] effects of thyroid hormones with fewer adverse effects, but none have received approval as of 2023.

Translations:Anti-obesity medication/7/en - Revision history

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