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Translations:Angiotensin II receptor blocker/31/en - Revision history
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<p><b>New page</b></p><div>{| class="wikitable"<br />
|+ Table 1: Comparison of ARB [[pharmacokinetics]]<br />
|-<br />
! Drug<br />
! Trade name<br />
! [[Biological half-life]] [hrs]<br />
! [[Cmax_(pharmacology)|Peak plasma concentration [Tmax] ]]<br />
! [[Protein binding]] [%]<br />
! [[Bioavailability]] [%]<br />
! Renal/hepatic [[Clearance (medicine)|clearance]] [%]<br />
! Food effect<br />
! Daily dosage [mg]<br />
! [[Metabolism]]/[[Transport protein|transporter]]<br />
|-<br />
| [[Losartan]]<br />
| Cozaar<br />
| 2 h<br />
| 1 hr <br />
| 98.7%<br />
| 33%<br />
| 10/90%<br />
| Minimal<br />
| 50–100<br />
| [[Sensitive substrates]]: [[CYP2C9]] and [[CYP3A4]]<br />
|-<br />
| [[Losartan#Pharmacokinetics|EXP 3174]] active metabolite of losartan<br />
| -<br />
| 6–9 hrs<br />
| 3–4 hrs after oral losartan administration<br />
| 99.8%<br />
| –<br />
| 50/50%<br />
| –<br />
| –<br />
| AUC reduced by phenytoin and rifampin by 63% and 40% respectively; specific CYP450 isozymes are unknown<br />
|-<br />
| [[Candesartan]]<br />
| Atacand<br />
| 9<br />
| 3–4 hrs<br />
| >99%<br />
| 15%<br />
| 60/40%<br />
| No<br />
| 4–32</div>
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