Fire at 01:07, 29 March 2024

2024-03-29T01:07:37Z

← Older revision		Revision as of 10:07, 29 March 2024
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	\| caption = {{{caption\|In humans, [[catecholamine]]s and phenethylaminergic [[trace amine]]s are derived from the [[amino acid]] {{nowrap\|[[Phenylalanine\|L-phenylalanine]]}}.}}}		\| caption = {{{caption\|In humans, [[catecholamine]]s and phenethylaminergic [[trace amine]]s are derived from the [[amino acid]] {{nowrap\|[[Phenylalanine\|L-phenylalanine]]}}.}}}
	\| header_background = {{{headerbg\|#F0F8FF}}}		\| header_background = {{{headerbg\|#F0F8FF}}}
	\| header = {{{header\|Biosynthetic pathways for [[catecholamine]]s and [[trace amine]]s in the [[human brain]]<ref name="Trace amine template 1">{{cite journal \| vauthors = Broadley KJ \| title = The vascular effects of trace amines and amphetamines \| journal = Pharmacology & Therapeutics\| volume = 125 \| issue = 3 \| pages = 363–375 \| date = March 2010 \| pmid = 19948186 \| doi = 10.1016/j.pharmthera.2009.11.005}}</ref><ref name="Trace amine template 2">{{cite journal \|vauthors=Lindemann L, Hoener MC \| title = A renaissance in trace amines inspired by a novel GPCR family \| journal = Trends in Pharmacological Sciences\| volume = 26 \| issue = 5 \| pages = 274–281 \| date = May 2005 \| pmid = 15860375 \| doi = 10.1016/j.tips.2005.03.007}}</ref><ref name="CYP2D6 tyramine-dopamine metabolism">{{cite journal \| vauthors = Wang X, Li J, Dong G, Yue J \| title = The endogenous substrates of brain CYP2D \| journal = European Journal of Pharmacology\| volume = 724 \| pages = 211–218 \| date = February 2014 \| pmid = 24374199 \| doi = 10.1016/j.ejphar.2013.12.025 \| quote = <!-- The highest level of brain CYP2D activity was found in the substantia nigra ... The in vitro and in vivo studies have shown the contribution of the alternative CYP2D-mediated dopamine synthesis to the concentration of this neurotransmitter although the classic biosynthetic route to dopamine from tyrosine is active. ... Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual behavior and emotion (Yu et al., 2003c). ... Rat CYP2D isoforms (2D2/2D4/2D18) are less efficient than human CYP2D6 for the generation of dopamine from p-tyramine. The K<sub>m</sub> values of the CYP2D isoforms are as follows: CYP2D6 (87–121 μm) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 (256 μm) for m-tyramine and CYP2D4 (433 μm) > CYP2D2 ≈ CYP2D6 > CYP2D18 (688 μm) for p-tyramine -->}}</ref>}}}		\| header = {{{header\|Biosynthetic pathways for [[catecholamine]]s and [[trace amine]]s in the [[human brain]]}}}
	\| alt = Graphic of catecholamine and trace amine biosynthesis		\| alt = Graphic of catecholamine and trace amine biosynthesis
	\| image = Catecholamine and trace amine biosynthesis.svg		\| image = Catecholamine and trace amine biosynthesis.svg

Fire: Created page with "{{Annotated image 4 | caption = {{{caption|In humans, catecholamines and phenethylaminergic trace amines are derived from the amino acid {{nowrap|L-phenylalanine}}.}}} | header_background = {{{headerbg|#F0F8FF}}} | header = {{{header|Biosynthetic pathways for catecholamines and trace amines in the human brain{{cite journal | vauthors = Broadley KJ | title = The vascular effects of trace amines a..."

2024-03-29T01:02:10Z

Created page with "{{Annotated image 4 | caption = {{{caption|In humans, catecholamines and phenethylaminergic trace amines are derived from the amino acid {{nowrap|L-phenylalanine}}.}}} | header_background = {{{headerbg|#F0F8FF}}} | header = {{{header|Biosynthetic pathways for catecholamines and trace amines in the human brain<ref name="Trace amine template 1">{{cite journal | vauthors = Broadley KJ | title = The vascular effects of trace amines a..."

New page

{{Annotated image 4
| caption = {{{caption|In humans, [[catecholamine]]s and phenethylaminergic [[trace amine]]s are derived from the [[amino acid]] {{nowrap|[[Phenylalanine|L-phenylalanine]]}}.}}}
| header_background = {{{headerbg|#F0F8FF}}}
| header = {{{header|Biosynthetic pathways for [[catecholamine]]s and [[trace amine]]s in the [[human brain]]<ref name="Trace amine template 1">{{cite journal | vauthors = Broadley KJ | title = The vascular effects of trace amines and amphetamines | journal = Pharmacology & Therapeutics| volume = 125 | issue = 3 | pages = 363–375 | date = March 2010 | pmid = 19948186 | doi = 10.1016/j.pharmthera.2009.11.005}}</ref><ref name="Trace amine template 2">{{cite journal |vauthors=Lindemann L, Hoener MC | title = A renaissance in trace amines inspired by a novel GPCR family | journal = Trends in Pharmacological Sciences| volume = 26 | issue = 5 | pages = 274–281 | date = May 2005 | pmid = 15860375 | doi = 10.1016/j.tips.2005.03.007}}</ref><ref name="CYP2D6 tyramine-dopamine metabolism">{{cite journal | vauthors = Wang X, Li J, Dong G, Yue J | title = The endogenous substrates of brain CYP2D | journal = European Journal of Pharmacology| volume = 724 | pages = 211–218 | date = February 2014 | pmid = 24374199 | doi = 10.1016/j.ejphar.2013.12.025 | quote = }}</ref>}}}
| alt = Graphic of catecholamine and trace amine biosynthesis
| image = Catecholamine and trace amine biosynthesis.svg
| image-width = 580
| image-left = 5
| image-top = 0
| align = {{{align|center}}}
| width = 590
| height = 465
| annot-font-size = 14
| annot-text-align = center
| annotations =

{{annotation|40|60|{{if pagename|Phenylalanine={{highlight|'''L-Phenylalanine'''}}|other=[[Phenylalanine|L-Phenylalanine]]}}}}
{{annotation|50|185|{{if pagename|Tyrosine={{highlight|'''L-Tyrosine'''}}|other=[[Tyrosine|L-Tyrosine]]}}}}
{{annotation|60|315|{{if pagename|L-DOPA={{highlight|'''L-DOPA'''}}|other=[[L-DOPA|L-DOPA]]}}}}
{{annotation|50|445|{{if pagename|Adrenaline={{highlight|'''Adrenaline'''}}|Epinephrine={{highlight|'''Epinephrine'''}}|Catecholamine={{highlight|[[Adrenaline|Epinephrine]]}}|other=[[Adrenaline|Epinephrine]]}}}}

{{annotation|245|60|{{if pagename|Phenethylamine={{highlight|'''Phenethylamine'''}}|Trace amine={{highlight|[[Phenethylamine]]}}|Neurobiological effects of physical exercise={{highlight|[[Phenethylamine]]}}|other=[[Phenethylamine]]}}}}
{{annotation|245|185|{{if pagename|Tyramine={{highlight|'''''p''-Tyramine'''}}|Trace amine={{highlight|[[Tyramine|''p''-Tyramine]]}}|other=[[Tyramine|''p''-Tyramine]]}}}}
{{annotation|245|315|{{if pagename|Dopamine={{highlight|'''Dopamine'''}}|Catecholamine={{highlight|[[Dopamine]]}}|Neurobiological effects of physical exercise={{highlight|[[Dopamine]]}}|other=[[Dopamine]]}}}}
{{annotation|245|445|{{if pagename|Norepinephrine={{highlight|'''Norepinephrine'''}}|Adrenaline=[[Noradrenaline]]|Catecholamine={{highlight|[[Norepinephrine]]}}|other=[[Norepinephrine]]}}}}

{{annotation|{{if pagename|N-Methylphenethylamine=405|other=415}}|60|{{if pagename|N-Methylphenethylamine={{highlight|'''''N''-Methylphenethylamine'''}}|Trace amine={{highlight|[[N-Methylphenethylamine|''N''-Methylphenethylamine]]}}|other=[[N-Methylphenethylamine|''N''-Methylphenethylamine]]}}}}
{{annotation|440|138|{{if pagename|N-Methyltyramine={{highlight|'''''N''-Methyltyramine'''}}|Trace amine={{highlight|[[N-Methyltyramine|''N''-Methyltyramine]]}}|other=[[N-Methyltyramine|''N''-Methyltyramine]]}}}}
{{annotation|440|228|{{if pagename|Octopamine={{highlight|'''''p''-Octopamine'''}}|Trace amine={{highlight|[[Octopamine|''p''-Octopamine]]}}|other=[[Octopamine|''p''-Octopamine]]}}}}
{{annotation|455|350|{{if pagename|Synephrine={{highlight|'''Synephrine'''}}|Trace amine={{highlight|[[Synephrine]]}}|other=[[Synephrine]]}}}}
{{annotation|445|445|{{if pagename|3-Methoxytyramine={{highlight|'''3-Methoxytyramine'''}}|Trace amine={{highlight|[[3-Methoxytyramine]]}}|other=[[3-Methoxytyramine]]}}}}

{{annotation|167|16|{{if pagename |Aromatic L-amino acid decarboxylase={{highlight|AADC}}|Neurobiological effects of physical exercise={{highlight|[[Aromatic L-amino acid decarboxylase|AADC]]}}|other=[[Aromatic L-amino acid decarboxylase|AADC]]}}}}
{{annotation|167|145|{{if pagename|Aromatic L-amino acid decarboxylase={{highlight|AADC}}|other=[[Aromatic L-amino acid decarboxylase|AADC]]}}}}
{{annotation|167|275|{{if pagename|Aromatic L-amino acid decarboxylase={{highlight|AADC}}|Neurobiological effects of physical exercise={{highlight|[[Aromatic L-amino acid decarboxylase|AADC]]}}|other=[[Aromatic L-amino acid decarboxylase|AADC]]}}}}
{{annotation|164|295|primary pathway|font-size=12}}

{{annotation|370|17|{{if pagename |Phenylethanolamine N-methyltransferase={{highlight|PNMT}} |other=[[Phenylethanolamine N-methyltransferase|PNMT]]}}}}
{{annotation|360|120|{{if pagename |Phenylethanolamine N-methyltransferase={{highlight|PNMT}} |other=[[Phenylethanolamine N-methyltransferase|PNMT]]}}}}
{{annotation|445|255|{{if pagename |Phenylethanolamine N-methyltransferase={{highlight|PNMT}} |other=[[Phenylethanolamine N-methyltransferase|PNMT]]}}}}
{{annotation|176|407|{{if pagename |Phenylethanolamine N-methyltransferase={{highlight|PNMT}} |other=[[Phenylethanolamine N-methyltransferase|PNMT]]}}}}

{{annotation|40|90|{{if pagename |Biopterin-dependent aromatic amino acid hydroxylase={{highlight|AAAH}} |other=[[Biopterin-dependent aromatic amino acid hydroxylase|AAAH]]}}}}
{{annotation|40|220|{{if pagename |Biopterin-dependent aromatic amino acid hydroxylase={{highlight|AAAH}} |other=[[Biopterin-dependent aromatic amino acid hydroxylase|AAAH]]}}}}
{{annotation|225|215|{{if pagename |CYP2D6=brain {{highlight|CYP2D6}}|other=brain [[CYP2D6]]}}}}
{{annotation|291|217|minor pathway|font-size=12|text-align=left}}
{{annotation|325|350|{{if pagename |Catechol O-methyltransferase=COMT |other=[[Catechol-O-methyltransferase|COMT]]}}}}
{{annotation|250|350|{{if pagename |Dopamine beta-hydroxylase={{highlight|DBH}} |other=[[Dopamine beta-hydroxylase|DBH]]}}}}
{{annotation|360|185|{{if pagename |Dopamine beta-hydroxylase={{highlight|DBH}} |other=[[Dopamine beta-hydroxylase|DBH]]}}}}

}}<noinclude>{{Documentation}}</noinclude>

Template:Catecholamine and trace amine biosynthesis - Revision history

Fire at 01:07, 29 March 2024