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Template:Cannabinoid receptor modulators - Revision history
2026-04-19T08:35:28Z
Revision history for this page on the wiki
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Fire: Created page with "{{Navbox | name = Cannabinoid receptor modulators | title = Cannabinoid receptor modulators | state = {{{state<includeonly>|collapsed</includeonly>}}} | bodyclass = hlist | groupstyle = text-align:center; | group1 = Receptor<br />{{nobold|(ligands)}} | list1 = {{Navbox|subgroup | groupstyle = text-align:center; | groupwidth = 4em; | group1 = {{abbrlink|CB<sub>1</sub>|Cannabin..."
2025-08-02T08:32:57Z
<p>Created page with "{{Navbox | name = Cannabinoid receptor modulators | title = <a href="/w/index.php?title=Cannabinoid_receptor&action=edit&redlink=1" class="new" title="Cannabinoid receptor (page does not exist)">Cannabinoid receptor</a> <a href="/w/index.php?title=Receptor_modulator&action=edit&redlink=1" class="new" title="Receptor modulator (page does not exist)">modulators</a> | state = {{{state<includeonly>|collapsed</includeonly>}}} | bodyclass = hlist | groupstyle = text-align:center; | group1 = <a href="/w/index.php?title=Receptor_(biochemistry)&action=edit&redlink=1" class="new" title="Receptor (biochemistry) (page does not exist)">Receptor</a><br />{{nobold|(<a href="/w/index.php?title=Ligand_(biochemistry)&action=edit&redlink=1" class="new" title="Ligand (biochemistry) (page does not exist)">ligands</a>)}} | list1 = {{Navbox|subgroup | groupstyle = text-align:center; | groupwidth = 4em; | group1 = {{abbrlink|CB<sub>1</sub>|Cannabin..."</p>
<p><b>New page</b></p><div>{{Navbox<br />
| name = Cannabinoid receptor modulators<br />
| title = [[Cannabinoid receptor]] [[receptor modulator|modulator]]s<br />
| state = {{{state<includeonly>|collapsed</includeonly>}}}<br />
| bodyclass = hlist<br />
| groupstyle = text-align:center;<br />
<br />
| group1 = [[Receptor (biochemistry)|Receptor]]<br />{{nobold|([[Ligand (biochemistry)|ligands]])}}<br />
| list1 = {{Navbox|subgroup<br />
| groupstyle = text-align:center;<br />
| groupwidth = 4em;<br />
<br />
| group1 = {{abbrlink|CB<sub>1</sub>|Cannabinoid receptor type 1}}<br />
| list1 =<br />
{{Navbox|child<br />
|group1=Agonists<br>''(abridged,<br>[[Template:Cannabinoids|full list]])''<br />
|list1=<br />
* [[2-Arachidonoylglycerol|2-AG]]<br />
* [[2-Arachidonyl glyceryl ether|2-AGE (noladin ether)]]<br />
* [[11-Hydroxy-THC]]<br />
* [[Amyrin|α-Amyrin · β-Amyrin]]<br />
* [[AB-CHMINACA]]<br />
* [[AM-1172]]<br />
* [[AM-1220]]<br />
* [[AM-1221]]<br />
* [[AM-1235]]<br />
* [[AM-2201]]<br />
* [[AM-2232]]<br />
* [[Anandamide]]<br />
* [[Arvanil]]<br />
* [[AZ-11713908]]<br />
* [[Cannabinol]]<br />
* [[CB-13]]<!--Peripherally restricted--><br />
* [[CP 47,497]]<br />
* [[CP 55,940]]<br />
* [[Dimethylheptylpyran]]<br />
* [[Docosatetraenoylethanolamide|DEA]]<br />
* [[Epicatechin gallate|ECG]]<br />
* [[Epigallocatechin gallate|EGCG]]<br />
* [[Catechin|Epicatechin]]<br />
* [[Gallocatechol|Gallocatechol (gallocatechin)]]<br />
* [[Honokiol]]<br />
* [[HU-210]]<br />
* [[JWH-007]]<br />
* [[JWH-015]]<br />
* [[JWH-018]]<br />
* [[JWH-073]]<br />
* [[Kavain]]<br />
* [[L-759,633]]<br />
* [[Levonantradol]]<br />
* [[Menabitan]]<br />
* [[Nabilone]]<br />
* [[Nabitan]]<br />
* [[N-Arachidonoyl dopamine|NADA]]<br />
* [[O-1812]]<br />
* [[Oleamide]]<br />
* [[Pravadoline]]<br />
* [[Serinolamide A]]<br />
* [[Tetrahydrocannabinol|THC (dronabinol)]]<br />
* [[UR-144]]<br />
* [[WIN 55,212-2]]<br />
* [[Yangonin]]<br />
|group2=Inverse agonists<br />
|list2=<br />
* [[AM-251 (drug)|AM-251]]<br />
* [[INV-202]]<br />
* [[Monlunabant]]<br />
* [[Rimonabant]]<br />
* [[Surinabant]]<br />
* [[Taranabant]]<br />
* [[TM-38837]]<br />
* [[Zevaquenabant]]<br />
|group3=Antagonists<br />
|list3=<br />
* [[AM-6545]]<br />
* [[Cannabidiol]]<br />
* [[Cannabigerol]]<br />
* [[Drinabant]]<br />
* [[Falcarinol|Falcarinol (carotatoxin)]]<br />
* [[Hemopressin]]<br />
* [[Ibipinabant]]<br />
* [[LY-320,135]]<br />
* [[MK-9470]]<br />
* [[NESS-0327]]<br />
* [[O-2050]]<br />
* [[Otenabant]]<br />
* [[PF-514273]]<br />
* [[PipISB]]<br />
* [[Rosonabant]]<br />
* [[Selonabant]]<br />
* [[Tetrahydrocannabivarin|THCV]]<br />
* [[VCHSR]]<br />
* [[Virodhamine]]<br />
}}<br />
<!-- * '''Unknown/unsorted:''' [[Methoxy arachidonyl fluorophosphonate|MAFP]] --><br />
<br />
| group2 = {{abbrlink|CB<sub>2</sub>|Cannabinoid receptor type 2}}<br />
| list2 =<br />
{{navbox|child<br />
|group1=Agonists<br />
|list1=<br />
* [[2-Arachidonoylglycerol|2-AG]]<br />
* [[2-Arachidonyl glyceryl ether|2-AGE (noladin ether)]]<br />
* [[3,3'-Diindolylmethane]]<br />
* [[4-O-Methylhonokiol]]<br />
* [[Amyrin|α-Amyrin · β-Amyrin]]<br />
* [[A-796,260]]<br />
* [[A-834,735]]<br />
* [[A-836,339]]<br />
* [[AM-1172]]<br />
* [[AM-1221]]<br />
* [[AM-1235]]<br />
* [[AM-1241]]<br />
* [[AM-2232]]<br />
* [[Anandamide]]<br />
* [[AZ-11713908]]<br />
* [[Cannabinol]]<br />
* [[Caryophyllene]]<br />
* [[CB-13]]<!--Peripherally restricted--><br />
* [[CBS-0550]]<br />
* [[CP 55,940]]<br />
* [[GW-405,833|GW-405,833 (L-768,242)]]<br />
* [[GW-842,166X]]<br />
* [[HU-308]]<br />
* [[JTE 7-31]]<br />
* [[JWH-007]]<br />
* [[JWH-015]]<br />
* [[JWH-018]]<br />
* [[JWH-73]]<br />
* [[JWH-133]]<br />
* [[L-759,633]]<br />
* [[L-759,656]]<br />
* [[Lenabasum|Lenabasum (anabasum)]]<br />
* [[Magnolol]]<br />
* [[MDA-19]]<br />
* [[Nabitan]]<br />
* [[N-Arachidonoyl dopamine|NADA]]<br />
* [[Olorinab|Olorinab (APD-371)]]<br />
* [[PF-03550096]]<br />
* [[S-444,823]]<br />
* [[SER-601]]<br />
* [[Serinolamide A]]<br />
* [[UR-144]]<br />
* [[Tedalinab]]<br />
* [[Tetrahydrocannabinol|THC (dronabinol)]]<br />
* [[Tetrahydrocannabivarin|THCV]]<br />
* [[Tetrahydromagnolol]]<br />
* [[Virodhamine]]<br />
<br />
|group2=Antagonists<br />
|list2=<br />
* [[4-O-Methylhonokiol]]<br />
* [[AM-630]]<br />
* [[BML-190]]<br />
* [[Cannabidiol]]<br />
* [[Honokiol]]<br />
* [[JTE-907]]<br />
* [[SR-144,528]]<br />
* [[WIN 54,461]]<br />
* [[WIN 56,098]]<br />
}}<br />
| group3 = [[NAGly receptor|{{abbr|NAGly|N-Arachidonyl glycine receptor}}<br />({{abbr|GPR18|G protein-coupled receptor 18}})]]<br />
| list3 =<br />
{{navbox|child|<br />
|group1=Agonists<br />
|list1=<br />
* [[Abnormal cannabidiol]]<br />
* [[Arachidonylcyclopropylamide|ACPA]]<br />
* [[AM-251 (drug)|AM251]]<br />
* [[Anandamide]]<br />
* [[Cannabidiol]]<br />
* [[N-Arachidonylglycine|NADGly]]<br />
* [[Tetrahydrocannabinol|THC (dronabinol)]]<br />
* [[O-1602]]<br />
<br />
|group2=Antagonists<br />
|list2=<br />
* [[PSB-CB5]]<br />
* [[O-1918]]<br />
}}<br />
| group4 = {{abbr|[[GPR55]]|G protein-coupled receptor 55}}<!--{{abbr|[[G protein-coupled receptor 55|GPR55]]|G protein-coupled receptor 55}}--><br />
| list4 =<br />
{{navbox|child|<br />
|group1=Agonists<br />
|list1=<br />
* [[2-Arachidonyl glyceryl ether|2-AGE (noladin ether)]]<br />
* [[2-Arachidonoyl lysophosphatidylinositol|2-ALPI]]<br />
* [[Abnormal cannabidiol]]<br />
* [[AM-251 (drug)|AM-251]]<br />
* [[CID1011163]]<!--PubChem compound ID--><br />
* [[CID1252842]]<!--PubChem compound ID--><br />
* [[CID1792579]]<!--PubChem compound ID--><br />
* [[CP 55,940]]<br />
* [[GSK-494581A]]<br />
* [[Lysophosphatidylinositol]]<br />
* [[ML-184]]<br />
* [[ML-185]]<br />
* [[ML-186]]<br />
* [[O-1602]]<br />
* [[Oleoylethanolamide]]<br />
* [[Palmitoylethanolamide]]<br />
* [[Tetrahydrocannabinol|THC (dronabinol)]]<br />
<br />
|group2=Antagonists<br />
|list2=<br />
* [[Cannabidiol]]<br />
* [[CID-16020046]]<br />
* [[ML-191]]<br />
* [[ML-192]]<br />
* [[ML-193]]<br />
* [[O-1918]]<br />
* [[PSB-SB-487]]<br />
* [[PSB-SB-1202]]<br />
* [[PSB-SB-1203]]<br />
* [[Tetrahydromagnolol]]<br />
}}<br />
| group5 = {{abbr|[[GPR119]]|G protein-coupled receptor 119}}<br />
| list5 =<br />
{{navbox|child|<br />
group1=Agonists<br />
|list1=<br />
* [[2-Oleoylglycerol]]<br />
* [[Anandamide]]<br />
* [[APD668]]<br />
* [[AR-231,453]]<br />
* [[AS-1269574]]<br />
* [[MBX-2982]]<br />
* [[N-Oleoyldopamine]]<br />
* [[Oleoylethanolamide]]<br />
* [[Olvanil]]<br />
* [[PSN-375,963]]<br />
* [[PSN-632,408]]<br />
<br />
<!--* '''Antagonists:'''--> <!--None known yet.---><br />
}}<br />
<!-- | group6 = Unsorted<br />
| list6 =<br />
* '''Agonists:''' [[Revosimeline]] --><br />
<br />
}}<br />
<br />
| group2 = [[Endocannabinoid transporter|Transporter]]<br />{{nobold|([[reuptake modulator|modulator]]s)}}<br />
| list2 = {{Navbox|subgroup<br />
| groupstyle = text-align:center;<br />
| groupwidth = 4em;<br />
<br />
| group1 = {{abbrlink|eCBTs|Endocannabinoid transporter}}<br />
| list1 =<br />
* '''Inhibitors:''' [[5'-DMH-CBD]]<br />
* [[AM404|AM-404]]<br />
* [[AM-1172]]<br />
* [[Arachidonoyl serotonin]]<br />
* [[Arvanil]]<br />
* [[Cannabidiol]]<br />
* [[Guineesine|Guineensine]]<br />
* [[LY-2183240]]<br />
* [[O-2093]]<br />
* [[OMDM-2]]<br />
* [[Paracetamol|Paracetamol (acetaminophen)]]<!--Prodrug--><br />
* [[SB-FI-26]]<br />
* [[UCM-707]]<br />
* [[URB597|URB-597]]<br />
* [[VDM-11]]<br />
* [[WOBE490]]<br />
* [[WOBE491]]<br />
* [[WOBE492]]<br />
<br />
}}<br />
<br />
| group3 = [[Enzyme]]<br />{{nobold|(modulators)}}<br />
| list3 = {{Navbox|subgroup<br />
| groupstyle = text-align:center;<br />
| groupwidth = 4em;<br />
<br />
| group1 = {{abbrlink|FAAH|Fatty acid amide hydrolase}}<br />
| list1 =<br />
* '''Inhibitors:''' [[4-Nonylphenylboronic acid]]<br />
* [[Arachidonyl trifluoromethyl ketone|AACOCF<sub>3</sub>]]<!--Non-selective--><br />
* [[AM404|AM-404]]<br />
* [[Arachidonoyl serotonin]]<br />
* [[BIA 10-2474]]<br />
* [[Biochanin A]]<br />
* [[Genistein]]<br />
* [[IDFP]]<br />
* [[JNJ-1661010]]<br />
* [[JNJ-42165279]]<br />
* [[JZL195|JZL-195]]<br />
* [[Kaempferol]]<br />
* [[LY-2183240]]<br />
* [[Methoxy arachidonyl fluorophosphonate|MAFP]]<br />
* [[Palmitoylisopropylamide]]<br />
* [[Paracetamol|Paracetamol (acetaminophen)]]<br />
* [[PF-3845]]<br />
* [[PF-750]]<br />
* [[Redafamdastat|Redafamdastat (JZP-150, PF-04457845)]]<br />
* [[SA-47]]<br />
* [[SA-57]]<br />
* [[TAK 21d]]<br />
* [[TC-F 2]]<br />
* [[UCM710]]<br />
* [[URB597|URB-597]]<br />
<br />
* '''Activators:''' [[PDP-EA]]<br />
<br />
| group2 = [[Monoacylglycerol lipase|MAGL]]<br />
| list2 =<br />
* '''Inhibitors:''' [[ABX-1431]]<!--In clinical trials--><br />
* [[IDFP]]<br />
* [[JJKK 048]]<br />
* [[JW 642]]<br />
* [[JZL184|JZL-184]]<br />
* [[JZL195|JZL-195]]<br />
* [[JZP-361]]<br />
* [[KML 29]]<br />
* [[Methoxy arachidonyl fluorophosphonate|MAFP]]<!--Non-selective--><br />
* [[MJN110]]<br />
* [[N-Arachidonoylmaleimide|NAM]]<!--Non-selective--><br />
* [[Pristimerin]]<!--Reversible--><br />
* [[URB602|URB-602]]<br />
<br />
| group3 = {{abbr|[[ABHD6]]|alpha/beta-Hydrolase domain containing 6}}<br />
| list3 =<br />
* '''Inhibitors:''' [[JZP-169]]<br />
* [[JZP-430]]<br />
* [[KT182]]<!--Peripherally restricted--><br />
* [[KT185]]<br />
* [[KT195]]<br />
* [[KT203]]<!--Peripherally restricted--><br />
* [[LEI-106]]<!--Dual DAGL-α/ABHD6 inhibitor--><br />
* [[ML294]]<br />
* [[ML295]]<br />
* [[ML296]]<!--Peripherally restricted--><br />
* [[UCM710]]<br />
* [[WWL-70]]<br />
<br />
| group4 = {{abbr|[[ABHD12]]|alpha/beta-Hydrolase domain containing 12}}<br />
| list4 =<br />
* '''Inhibitors:''' [[Betulinic acid]]<br />
* [[Maslinic acid]]<br />
* [[Methoxy arachidonyl fluorophosphonate|MAFP]]<!--Non-selective--><br />
* [[Oleanolic acid]]<br />
* [[Orlistat|Orlistat (tetrahydrolipstatin)]]<!--Non-selective--><br />
* [[Ursolic acid]]<br />
<br />
}}<br />
<br />
| group4 = Others<br />
| list4 =<br />
* '''Precursors:''' [[Phosphatidylethanolamine]]<br />
* [[N-Acylphosphatidylethanolamine|NAPE]]<br />
* [[Diglyceride|Diacylglycerol]]<br />
<br />
* '''Others:''' [[2-Palmitoylglycerol|2-PG]] ''(directly potentiates activity of 2-AG at CB<sub>1</sub> receptor)''<br />
* [[ARN-272]] ''(FAAH-like anandamide transporter inhibitor)''<br />
<br />
| below =<br />
;See also<br />
:'' [[Template:Receptor modulators|Receptor/signaling modulators]]''<br />
:'' [[Template:Cannabinoids|Cannabinoids]] (cannabinoids by structure)''<br />
<br />
}}<noinclude><br />
{{Documentation}}<br />
</noinclude></div>
Fire