Fire: Created page with "{{Navbox | name = Amino acid metabolism enzymes | title = Metabolism: Protein metabolism, synthesis and catabolism enzymes | state = {{{state|}}} | listclass = hlist | above= ''Essential amino acids are in Capitals'' | group1 = K→acetyl-CoA | list1 = {{Navbox|child | group1 = LYSINE→ | list1 = * Saccharopine dehydrogenase * Glutaryl-CoA dehydrogenase | group2..."

2024-01-22T09:47:07Z

Created page with "{{Navbox | name = Amino acid metabolism enzymes | title = Metabolism: Protein metabolism, synthesis and catabolism enzymes | state = {{{state|}}} | listclass = hlist | above= ''Essential amino acids are in Capitals'' | group1 = K→acetyl-CoA | list1 = {{Navbox|child | group1 = LYSINE→ | list1 = * Saccharopine dehydrogenase * Glutaryl-CoA dehydrogenase | group2..."

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{{Navbox
| name = Amino acid metabolism enzymes
| title = [[Metabolism]]: [[Protein metabolism]], [[Amino acid synthesis|synthesis]] and catabolism [[enzyme]]s
| state = {{{state|}}}
| listclass = hlist

| above= ''[[Essential amino acid]]s are in Capitals''

| group1 = [[Ketogenic amino acid|K]]→[[acetyl-CoA]]
| list1 = {{Navbox|child

| group1 = [[lysine|LYSINE]]→
| list1 =
* [[Saccharopine dehydrogenase]]
* [[Glutaryl-CoA dehydrogenase]]

| group2 = [[leucine|LEUCINE]]→
| list2 =
* [[3-Hydroxybutyryl-CoA dehydrogenase]]
* [[Branched-chain amino acid aminotransferase]]
* [[Branched-chain alpha-keto acid dehydrogenase complex]]
* [[Enoyl-CoA hydratase]]
* [[3-hydroxy-3-methylglutaryl-CoA lyase|HMG-CoA lyase]]
* [[HMG-CoA reductase]]
* [[Isovaleryl coenzyme A dehydrogenase]]
* [[α-ketoisocaproate dioxygenase|α-Ketoisocaproate dioxygenase]]
* [[Leucine 2,3-aminomutase]]
* [[Methylcrotonyl-CoA carboxylase]]
* [[Methylglutaconyl-CoA hydratase]]
(See [[Template:Leucine metabolism in humans]] – this diagram does not include the pathway for β-leucine synthesis via leucine 2,3-aminomutase)

| group3 = [[tryptophan|TRYPTOPHAN]]→
| list3 =
* [[Indoleamine 2,3-dioxygenase]]/[[Tryptophan 2,3-dioxygenase]]
* [[Arylformamidase]]
* [[Kynureninase]]
* [[3-hydroxyanthranilate oxidase]]
* [[Aminocarboxymuconate-semialdehyde decarboxylase]]
* [[Aminomuconate-semialdehyde dehydrogenase]]

| group4 = [[phenylalanine|PHENYLALANINE]]→[[tyrosine]]→
| list4 =
* (see below)

}}

| group2 = [[Glucogenic amino acid|G]]
| list2 = {{Navbox|child

| group1 = G→[[pyruvate]]<br />→[[citrate]]
| list1 = {{Navbox|child

| group1 = [[glycine]]→[[serine]]→
| list1 =
* [[Serine hydroxymethyltransferase]]
* [[Serine dehydratase]]

* [[glycine]]→[[creatine]]: [[Guanidinoacetate N-methyltransferase]]
* [[Creatine kinase]]

| group2 = [[alanine]]→
| list2 =
* [[Alanine transaminase]]

| group3 = [[cysteine]]→
| list3 =
* [[D-cysteine desulfhydrase]]

| group4 = [[threonine]]→
| list4 =
* [[L-threonine dehydrogenase]]

}}

| group3 = G→[[glutamate]]→<br />[[alpha-Ketoglutaric acid|α-ketoglutarate]]
| list3 = {{Navbox|child

| group5 = [[histidine|HISTIDINE]]→
| list5 =
* [[Histidine ammonia-lyase]]
* [[Urocanase|Urocanate hydratase]]
* [[Formiminotransferase cyclodeaminase]]

| group6 = [[proline]]→
| list6 =
* [[Proline oxidase]]
* [[Pyrroline-5-carboxylate reductase]]
* [[1-Pyrroline-5-carboxylate dehydrogenase]]/[[Aldehyde dehydrogenase 4 family, member A1|ALDH4A1]]
* [[PYCR1]]

| group7 = [[arginine]]→
| list7 =
* [[Ornithine aminotransferase]]
* [[Ornithine decarboxylase]]
* [[Agmatinase]]

| group8 = →[[alpha-ketoglutarate]]→TCA
| list8 =
* [[Glutamate dehydrogenase]]

| group9 = Other
| list9 =
* [[cysteine]]+[[glutamate]]→[[glutathione]]: [[Gamma-glutamylcysteine synthetase]]
* [[Glutathione synthetase]]
* [[Gamma-glutamyl transpeptidase]]

* [[glutamate]]→[[glutamine]]: [[Glutamine synthetase]]
* [[Glutaminase]]

}}

| group4 = G→[[propionyl-CoA]]→<br />[[succinyl-CoA]]
| list4 = {{Navbox|child

| group1 = [[valine|VALINE]]→
| list1 =
* [[Branched-chain amino acid aminotransferase]]
* [[Branched-chain alpha-keto acid dehydrogenase complex]]
* [[Enoyl-CoA hydratase]]
* [[3-hydroxyisobutyryl-CoA hydrolase]]
* [[3-hydroxyisobutyrate dehydrogenase]]
* [[Methylmalonate-semialdehyde dehydrogenase (acylating)|Methylmalonate semialdehyde dehydrogenase]]

| group2 = [[isoleucine|ISOLEUCINE]]→
| list2 =
* [[Branched-chain amino acid aminotransferase]]
* [[Branched-chain alpha-keto acid dehydrogenase complex]]
* [[3-hydroxy-2-methylbutyryl-CoA dehydrogenase]]

| group3 = [[methionine|METHIONINE]]→
| list3 =
* ''[[Methionine#Generation of homocysteine|generation of homocysteine]]:'' [[Methionine adenosyltransferase]]
* [[Adenosylhomocysteinase]]

* ''[[Methionine#Regeneration of methionine|regeneration of methionine]]:'' [[Methionine synthase]]/[[methionine synthase|Homocysteine methyltransferase]]
* [[Betaine-homocysteine S-methyltransferase|Betaine-homocysteine methyltransferase]]

* ''[[Methionine#Conversion to cysteine|conversion to cysteine]]:'' [[Cystathionine beta synthase]]
* [[Cystathionine gamma-lyase]]

| group4 = [[threonine|THREONINE]]→
| list4 =
* [[Threonine aldolase]]

| group5 = →[[succinyl-CoA]]→TCA
| list5 =
* [[Propionyl-CoA carboxylase]]
* [[Methylmalonyl CoA epimerase]]
* [[Methylmalonyl-CoA mutase]]

}}

| group5 = G→[[fumarate]]
| list5 = {{Navbox|child

| group13 = [[phenylalanine|PHENYLALANINE]]→[[tyrosine]]→
| list13 =
* [[Phenylalanine hydroxylase]]
* [[Tyrosine aminotransferase]]
* [[4-Hydroxyphenylpyruvate dioxygenase]]
* [[Homogentisate 1,2-dioxygenase]]
* [[Fumarylacetoacetate hydrolase]]

* [[tyrosine]]→[[melanin]]: [[Tyrosinase]]

}}

| group6 = G→[[Oxaloacetic acid|oxaloacetate]]
| list6 = {{Navbox|child

| group14 = [[asparagine]]→[[aspartate]]→
| list14 =
* [[Asparaginase]]/[[Asparagine synthetase]]
* [[Aspartate transaminase]]

}}
}}

}}<noinclude>
{{collapsible option}}
[[Category:Amino acid metabolic pathway navigational boxes]]
</noinclude>

Template:Amino acid metabolism enzymes - Revision history