Tacalcitol/ja - Revision history

Fire: Created page with "{{Antipsoriatics/ja}} {{Vitamin D receptor modulators/ja}}"

2024-04-12T14:05:16Z

Created page with "{{Antipsoriatics/ja}} {{Vitamin D receptor modulators/ja}}"

← Older revision		Revision as of 23:05, 12 April 2024
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	また、[[vitiligo/ja\|白斑]]や[[Hailey-Hailey disease/ja\|ハイリーハイリー病]]にも使用されている。		また、[[vitiligo/ja\|白斑]]や[[Hailey-Hailey disease/ja\|ハイリーハイリー病]]にも使用されている。

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~		{{Antipsoriatics/ja}}
	{{Antipsoriatics}}		{{Vitamin D receptor modulators/ja}}
	{{Vitamin D receptor modulators}}
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	~~{{二次利用\|date=11 February 2024}}~~
	[[Category:Secosteroids]]		[[Category:Secosteroids]]
	[[Category:Vitamin D]]		[[Category:Vitamin D]]
	{{Vitamins}}		{{Vitamins/ja}}
	~~</div>~~

Fire: Created page with "また、白斑やハイリーハイリー病にも使用されている。"

2024-04-12T14:04:54Z

Created page with "また、白斑やハイリーハイリー病にも使用されている。"

← Older revision		Revision as of 23:04, 12 April 2024
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	皮膚細胞の過剰なターンオーバーを抑える作用があるため、通常、[[psoriasis/ja\|乾癬]]や慢性[[chapped lips/ja\|ひび割れ唇]]などの重度の乾燥肌の治療薬として、開業医や皮膚科医から処方される。軟膏またはローションとして入手できる。		皮膚細胞の過剰なターンオーバーを抑える作用があるため、通常、[[psoriasis/ja\|乾癬]]や慢性[[chapped lips/ja\|ひび割れ唇]]などの重度の乾燥肌の治療薬として、開業医や皮膚科医から処方される。軟膏またはローションとして入手できる。

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~		また、[[vitiligo/ja\|白斑]]や[[Hailey-Hailey disease/ja\|ハイリーハイリー病]]にも使用されている。
	~~It has also been used for~~ [[vitiligo]] ~~and~~ [[Hailey-Hailey disease]].
	~~</div>~~

	<div lang="en" dir="ltr" class="mw-content-ltr">		<div lang="en" dir="ltr" class="mw-content-ltr">

Fire: Created page with " | tradename = | Drugs.com = {{drugs.com|international|tacalcitol}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | C=27 | H=44 | O=3 | synonyms = (1α,24''R'')-1,24-Dihydroxyvitamin D₃ | smiles = O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,..."

2024-04-12T14:03:38Z

Created page with " | C=27 | H=44 | O=3 | synonyms = (1α,24''R'')-1,24-Dihydroxyvitamin D<sub>3</sub> | smiles = O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,..."

← Older revision		Revision as of 23:03, 12 April 2024
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	}}		}}

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~		'''タカルシトール'''（'''Tacalcitol'''）（1,24-dihydroxyvitamin D<sub>3</sub>）は合成[[vitamin D3\|ビタミンD<sub>3</sub>]]類似体である。タカルシトールは'''Curatoderm'''や'''Bonalfa'''などの名称で販売されている。
	'''Tacalcitol''' (1,24-dihydroxyvitamin D<sub>3</sub>~~) is a synthetic~~ [[vitamin D3\|~~vitamin D~~<sub>3</sub>]] ~~analog. Tacalcitol is marketed under several names, including~~ '''Curatoderm''' ~~and~~ '''Bonalfa'''.
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~		[[WHO Model List of Essential Medicines/ja\|世界保健機関の必須医薬品リスト]]に掲載されている。
	~~It is on the~~ [[WHO Model List of Essential Medicines\|~~World Health Organization's List of Essential Medicines~~]].
	~~</div>~~

	<div lang="en" dir="ltr" class="mw-content-ltr">		<div lang="en" dir="ltr" class="mw-content-ltr">

Fire: Created page with " | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 57333-96-7 | ATC_prefix = D05 | ATC_suffix = AX04 | PubChem = 5283734 | IUPHAR_ligand = 2780 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|changed|FDA}} | UNII = C2W72OJ5ZU | ChEBI = 32176 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 340361 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4446823"

2024-04-12T14:02:44Z

Created page with " | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 57333-96-7 | ATC_prefix = D05 | ATC_suffix = AX04 | PubChem = 5283734 | IUPHAR_ligand = 2780 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|changed|FDA}} | UNII = C2W72OJ5ZU | ChEBI = 32176 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 340361 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4446823"

← Older revision		Revision as of 23:02, 12 April 2024
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	\| ChemSpiderID = 4446823		\| ChemSpiderID = 4446823

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	<!--Chemical data-->		<!--Chemical data-->
	\| C=27 \| H=44 \| O=3		\| C=27 \| H=44 \| O=3
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	\| StdInChIKey = BJYLYJCXYAMOFT-RSFVBTMBSA-N		\| StdInChIKey = BJYLYJCXYAMOFT-RSFVBTMBSA-N
	}}		}}
	~~</div>~~

	<div lang="en" dir="ltr" class="mw-content-ltr">		<div lang="en" dir="ltr" class="mw-content-ltr">

Fire: Created page with "{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 376121485 | IUPAC_name = (1''S'',3''R'',5''Z'',7''E'',24''R'')-9,10-secocholesta-5,7,10-triene-1,3,24-triol | image = Tacalcitol.svg"

2024-04-12T14:02:29Z

Created page with "{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 376121485 | IUPAC_name = (1''S'',3''R'',5''Z'',7''E'',24''R'')-9,10-secocholesta-5,7,10-triene-1,3,24-triol | image = Tacalcitol.svg"

← Older revision		Revision as of 23:02, 12 April 2024
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	<languages />		<languages />
	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	~~{{Short description\|Chemical compound}}~~
	{{Drugbox		{{Drugbox
	\| Verifiedfields = changed		\| Verifiedfields = changed
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	\| IUPAC_name = (1''S'',3''R'',5''Z'',7''E'',24''R'')-9,10-secocholesta-5,7,10-triene-1,3,24-triol		\| IUPAC_name = (1''S'',3''R'',5''Z'',7''E'',24''R'')-9,10-secocholesta-5,7,10-triene-1,3,24-triol
	\| image = Tacalcitol.svg		\| image = Tacalcitol.svg
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	<!--Clinical data-->		<!--Clinical data-->
	\| tradename =		\| tradename =
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	\| legal_status =		\| legal_status =
	\| routes_of_administration = Topical		\| routes_of_administration = Topical
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	<!--Pharmacokinetic data-->		<!--Pharmacokinetic data-->
	\| bioavailability =		\| bioavailability =
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	\| metabolism =		\| metabolism =
	\| elimination_half-life =		\| elimination_half-life =
	\| excretion =		\| excretion =
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	<!--Identifiers-->		<!--Identifiers-->
	\| CAS_number_Ref = {{cascite\|correct\|??}}		\| CAS_number_Ref = {{cascite\|correct\|??}}
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	\| ChemSpiderID_Ref = {{chemspidercite\|changed\|chemspider}}		\| ChemSpiderID_Ref = {{chemspidercite\|changed\|chemspider}}
	\| ChemSpiderID = 4446823		\| ChemSpiderID = 4446823
	~~</div>~~

	<div lang="en" dir="ltr" class="mw-content-ltr">		<div lang="en" dir="ltr" class="mw-content-ltr">

Fire: Created page with "タカルシトール"

2024-04-12T14:02:16Z

Created page with "タカルシトール"

New page

<languages />
<div lang="en" dir="ltr" class="mw-content-ltr">
{{Short description|Chemical compound}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 376121485
| IUPAC_name = (1''S'',3''R'',5''Z'',7''E'',24''R'')-9,10-secocholesta-5,7,10-triene-1,3,24-triol
| image = Tacalcitol.svg
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">

| tradename =
| Drugs.com = {{drugs.com|international|tacalcitol}}
| pregnancy_AU = 
| pregnancy_US = 
| pregnancy_category =
| legal_AU = 
| legal_CA = 
| legal_UK = 
| legal_US = 
| legal_status =
| routes_of_administration = Topical
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">

| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">

| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 57333-96-7
| ATC_prefix = D05
| ATC_suffix = AX04
| PubChem = 5283734
| IUPHAR_ligand = 2780
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = C2W72OJ5ZU
| ChEBI = 32176
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 340361
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 4446823
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">

| C=27 | H=44 | O=3
| synonyms = (1α,24''R'')-1,24-Dihydroxyvitamin D<sub>3</sub>
| smiles = O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = BJYLYJCXYAMOFT-RSFVBTMBSA-N
}}
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
'''Tacalcitol''' (1,24-dihydroxyvitamin D<sub>3</sub>) is a synthetic [[vitamin D3|vitamin D<sub>3</sub>]] analog. Tacalcitol is marketed under several names, including '''Curatoderm''' and '''Bonalfa'''.
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
It is on the [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
==Mechanism==
Tacalcitol reduces excessive cell turnover in the epidermis by interacting with [[vitamin D receptor]]s on [[keratinocytes]].
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
==Uses==
It is usually prescribed by a general practitioner or dermatologist for the treatment of [[psoriasis]], chronic [[chapped lips]] and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover. It is available as an ointment or lotion.
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
It has also been used for [[vitiligo]] and [[Hailey-Hailey disease]].
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
{{Antipsoriatics}}
{{Vitamin D receptor modulators}}
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
{{二次利用|date=11 February 2024}}
[[Category:Secosteroids]]
[[Category:Vitamin D]]
{{Vitamins}}
</div>