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Tacalcitol/en - Revision history
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{{Short description|Chemical compound}}<br />
{{Drugbox<br />
| Verifiedfields = changed<br />
| Watchedfields = changed<br />
| verifiedrevid = 376121485<br />
| IUPAC_name = (1''S'',3''R'',5''Z'',7''E'',24''R'')-9,10-secocholesta-5,7,10-triene-1,3,24-triol<br />
| image = Tacalcitol.svg<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| Drugs.com = {{drugs.com|international|tacalcitol}}<br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --><br />
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --><br />
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --><br />
| legal_status = <br />
| routes_of_administration = Topical<br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
<br />
<!--Identifiers--><br />
| CAS_number_Ref = {{cascite|correct|??}}<br />
| CAS_number = 57333-96-7<br />
| ATC_prefix = D05<br />
| ATC_suffix = AX04<br />
| PubChem = 5283734<br />
| IUPHAR_ligand = 2780<br />
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}<br />
| DrugBank = <br />
| UNII_Ref = {{fdacite|changed|FDA}}<br />
| UNII = C2W72OJ5ZU<br />
| ChEBI = 32176<br />
| ChEMBL_Ref = {{ebicite|changed|EBI}}<br />
| ChEMBL = 340361<br />
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}<br />
| ChemSpiderID = 4446823<br />
<br />
<!--Chemical data--><br />
| C=27 | H=44 | O=3 <br />
| synonyms = (1α,24''R'')-1,24-Dihydroxyvitamin D<sub>3</sub><br />
| smiles = O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C<br />
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChI = 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1<br />
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChIKey = BJYLYJCXYAMOFT-RSFVBTMBSA-N<br />
}}<br />
<br />
'''Tacalcitol''' (1,24-dihydroxyvitamin D<sub>3</sub>) is a synthetic [[vitamin D3|vitamin D<sub>3</sub>]] analog. Tacalcitol is marketed under several names, including '''Curatoderm''' and '''Bonalfa'''.<br />
<br />
It is on the [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].<br />
<br />
==Mechanism==<br />
Tacalcitol reduces excessive cell turnover in the epidermis by interacting with [[vitamin D receptor]]s on [[keratinocytes]].<br />
<br />
==Uses==<br />
It is usually prescribed by a general practitioner or dermatologist for the treatment of [[psoriasis]], chronic [[chapped lips]] and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover. It is available as an ointment or lotion.<br />
<br />
It has also been used for [[vitiligo]] and [[Hailey-Hailey disease]].<br />
<br />
{{Antipsoriatics}}<br />
{{Vitamin D receptor modulators}}<br />
<br />
{{二次利用|date=11 February 2024}}<br />
[[Category:Secosteroids]]<br />
[[Category:Vitamin D]]<br />
{{Vitamins}}</div>
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