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{{Short description|Chemical compound}}<br />
{{Drugbox<br />
| IUPAC_name = ''N''-[(4-amino-2-methylpyrimidin-5-yl)methyl]-''N''-[(1''E'')-4-hydroxy-1-methyl-2-(propyldisulfanyl)but-1-en-1-yl]formamide<br />
| image = Prosultiamine.png<br />
| alt = Skeletal formula of prosultiamine<br />
| width = 240<br />
| image2 = Prosultiamine 3D ball.png<br />
| alt2 = Ball-and-stick model of the prosultiamine molecule<br />
| width2 = 260<br />
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<!--Clinical data--><br />
| tradename = <br />
| Drugs.com = {{drugs.com|international|prosultiamine}}<br />
| pregnancy_category = <br />
| legal_status = Rx-only<br />
| routes_of_administration = [[Mouth|Oral]]<br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion =<br />
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<!--Identifiers--><br />
| CAS_number = 59-58-5<br />
| ATC_prefix = None<br />
| ATC_suffix = <br />
| PubChem = 5355019<br />
| ChemSpiderID = 4511078<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = UI32MM3XE3<br />
<br />
<!--Chemical data--><br />
| C=15 | H=24 | N=4 | O=2 | S=2 <br />
| smiles = O=CN(\C(=C(\SSCCC)CCO)C)Cc1cnc(nc1N)C<br />
}}<br />
<br />
'''Prosultiamine''' ([[International Nonproprietary Name|INN]]; also known as '''thiamine propyl disulfide''' or '''TPD'''; brand name '''Jubedel''',) is a [[disulfide]] [[thiamine]] [[derivative (chemistry)|derivative]] discovered in garlic in [[Japan]] in the 1950s, and is similar to [[allithiamine]]. It was developed as a treatment for [[Thiamine#Deficiency|vitamin B<sub>1</sub> deficiency]]. It has improved [[lipid]] [[solubility]] relative to thiamine and is not rate-limited by dependency on intestinal [[membrane transport protein|transporter]]s for absorption, hence the reasoning for its development.<br />
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==Research==<br />
It has been studied as a potential treatment for infection with [[human T-lymphotropic virus]] (HTLV), since it has been shown to reduce viral load and symptoms.<br />
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== See also ==<br />
* [[Vitamin B1 analogue|Vitamin B<sub>1</sub> analogue]]<br />
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{{Vitamins}}<br />
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{{二次利用|date=2 March 2024}}<br />
[[Category:Formamides]]<br />
[[Category:Organic disulfides]]<br />
[[Category:Aminopyrimidines]]<br />
[[Category:Thiamine]]</div>FuzzyBot