Fursultiamine/ja - Revision history

Fire: Created page with "Category:Formamides Category:Organic disulfides Category:Aminopyrimidines Category:Tetrahydrofurans Category:Prodrugs Category:Thiamine"

2024-04-03T00:45:03Z

Created page with "Category:Formamides Category:Organic disulfides Category:Aminopyrimidines Category:Tetrahydrofurans Category:Prodrugs Category:Thiamine"

← Older revision		Revision as of 09:45, 3 April 2024
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	* [[Vitamin B1 analogue/ja\|ビタミンB<sub>1</sub>類似体]]		* [[Vitamin B1 analogue/ja\|ビタミンB<sub>1</sub>類似体]]

	~~<div lang~~=~~"en" dir~~=~~"ltr" class="mw-content-ltr">~~		== さらに読む ==
	~~== Further reading~~ ==
	* {{cite journal \| vauthors = Lonsdale D \| title = Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent \| journal = Medical Science Monitor \| volume = 10 \| issue = 9 \| pages = RA199–203 \| date = September 2004 \| pmid = 15328496 \| url = http://www.medscimonit.com/fulltxt.php?ICID=11763 }}		* {{cite journal \| vauthors = Lonsdale D \| title = Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent \| journal = Medical Science Monitor \| volume = 10 \| issue = 9 \| pages = RA199–203 \| date = September 2004 \| pmid = 15328496 \| url = http://www.medscimonit.com/fulltxt.php?ICID=11763 }}
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~		{{Vitamins/ja}}
	{{Vitamins}}
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	~~{{二次利用\|date=6 April 2023}}~~
	[[Category:Formamides]]		[[Category:Formamides]]
	[[Category:Organic disulfides]]		[[Category:Organic disulfides]]
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	[[Category:Prodrugs]]		[[Category:Prodrugs]]
	[[Category:Thiamine]]		[[Category:Thiamine]]
	~~</div>~~

Fire: Created page with "== こちらも参照 == * ビタミンB₁類似体"

2024-04-03T00:44:40Z

Created page with "== こちらも参照 == * ビタミンB<sub>1</sub>類似体"

← Older revision		Revision as of 09:44, 3 April 2024
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	1960年代に[[:ja:日本\|日本]]で、[[Thiamine/ja#Deficiency\|ビタミンB<sub>1</sub>欠乏症]]（すなわち[[beriberi/ja\|脚気]]）の治療用に[[lipophilicity/ja\|親油性]]を改善した形態のチアミンを開発する目的で[[allithiamine/ja\|アリチアミン]]から合成され、その後日本だけでなく、[[:ja:スペイン\|スペイン]]、[[:ja:オーストリア\|オーストリア]]、[[:ja:ドイツ\|ドイツ]]、[[:ja:アメリカ\|アメリカ]]でも商業化された。		1960年代に[[:ja:日本\|日本]]で、[[Thiamine/ja#Deficiency\|ビタミンB<sub>1</sub>欠乏症]]（すなわち[[beriberi/ja\|脚気]]）の治療用に[[lipophilicity/ja\|親油性]]を改善した形態のチアミンを開発する目的で[[allithiamine/ja\|アリチアミン]]から合成され、その後日本だけでなく、[[:ja:スペイン\|スペイン]]、[[:ja:オーストリア\|オーストリア]]、[[:ja:ドイツ\|ドイツ]]、[[:ja:アメリカ\|アメリカ]]でも商業化された。

	~~<div lang="en" dir~~=~~"ltr" class~~=~~"mw-content-ltr">~~		== こちらも参照 ==
	~~== See also~~ ==		* [[Vitamin B1 analogue/ja\|ビタミンB<sub>1</sub>類似体]]
	* [[Vitamin B1 analogue\|~~Vitamin B~~<sub>1</sub> ~~analogue~~]]
	~~</div>~~

	<div lang="en" dir="ltr" class="mw-content-ltr">		<div lang="en" dir="ltr" class="mw-content-ltr">

Fire: Created page with "'''フルスルチアミン'''（INN、化学名'''チアミンテトラヒドロフルフリルジスルフィド'''または'''TTFD'''；商品名'''Adventan'''、'''Alinamin-F'''、'''Benlipoid'''、'''Bevitol Lipophil'''、'''Judolor'''、'''Lipothiamine'''）は、チアミン欠乏症の治療に用いられる医薬品およびビタミン剤である。化学的にはジスルフィド..."

2024-04-03T00:44:13Z

Created page with "'''フルスルチアミン'''（INN、化学名'''チアミンテトラヒドロフルフリルジスルフィド'''または'''TTFD'''；商品名'''Adventan'''、'''Alinamin-F'''、'''Benlipoid'''、'''Bevitol Lipophil'''、'''Judolor'''、'''Lipothiamine'''）は、チアミン欠乏症の治療に用いられる医薬品およびビタミン剤である。化学的にはジスルフィド..."

← Older revision		Revision as of 09:44, 3 April 2024
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	'''フルスルチアミン'''（[[:en:International Nonproprietary Name\|INN]]、化学名'''チアミンテトラヒドロフルフリルジスルフィド'''または'''TTFD'''；商品名'''Adventan'''、'''Alinamin-F'''、'''Benlipoid'''、'''Bevitol Lipophil'''、'''Judolor'''、'''Lipothiamine'''）は、[[thiamine/ja\|チアミン]]欠乏症の治療に用いられる医薬品およびビタミン剤である。化学的には[[disulfide/ja\|ジスルフィド]]である。化学的にはチアミンの[[derivative (chemistry)/ja\|誘導体]]であり、[[allithiamine/ja\|アリチアミン]]と構造が似ている。		'''フルスルチアミン'''（[[:en:International Nonproprietary Name\|INN]]、化学名'''チアミンテトラヒドロフルフリルジスルフィド'''または'''TTFD'''；商品名'''Adventan'''、'''Alinamin-F'''、'''Benlipoid'''、'''Bevitol Lipophil'''、'''Judolor'''、'''Lipothiamine'''）は、[[thiamine/ja\|チアミン]]欠乏症の治療に用いられる医薬品およびビタミン剤である。化学的には[[disulfide/ja\|ジスルフィド]]である。化学的にはチアミンの[[derivative (chemistry)/ja\|誘導体]]であり、[[allithiamine/ja\|アリチアミン]]と構造が似ている。

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~		1960年代に[[:ja:日本\|日本]]で、[[Thiamine/ja#Deficiency\|ビタミンB<sub>1</sub>欠乏症]]（すなわち[[beriberi/ja\|脚気]]）の治療用に[[lipophilicity/ja\|親油性]]を改善した形態のチアミンを開発する目的で[[allithiamine/ja\|アリチアミン]]から合成され、その後日本だけでなく、[[:ja:スペイン\|スペイン]]、[[:ja:オーストリア\|オーストリア]]、[[:ja:ドイツ\|ドイツ]]、[[:ja:アメリカ\|アメリカ]]でも商業化された。
	~~It was synthesized in~~ [[~~Japan]] in the 1960s from [[allithiamine~~]] ~~for the purpose of developing forms of thiamine with improved [[lipophilicity]] for treating~~ [[Thiamine#Deficiency\|~~vitamin B~~<sub>1</sub> ~~deficiency~~]] ~~(i.e.,~~ [[beriberi]]~~), It was subsequently commercialized not only in Japan but also in~~ [[~~Spain~~]], [[~~Austria~~]], [[~~Germany~~]]~~, and the~~ [[~~United States~~]].
	~~</div>~~

	<div lang="en" dir="ltr" class="mw-content-ltr">		<div lang="en" dir="ltr" class="mw-content-ltr">

Fire: Created page with " | tradename = | Drugs.com = {{drugs.com|international|fursultiamine}} | pregnancy_category = | legal_status = otc | routes_of_administration = Oral"

2024-04-03T00:42:52Z

Created page with " | tradename = | Drugs.com = {{drugs.com|international|fursultiamine}} | pregnancy_category = | legal_status = otc | routes_of_administration = Oral"

← Older revision		Revision as of 09:42, 3 April 2024
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	}}		}}

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~		'''フルスルチアミン'''（[[:en:International Nonproprietary Name\|INN]]、化学名'''チアミンテトラヒドロフルフリルジスルフィド'''または'''TTFD'''；商品名'''Adventan'''、'''Alinamin-F'''、'''Benlipoid'''、'''Bevitol Lipophil'''、'''Judolor'''、'''Lipothiamine'''）は、[[thiamine/ja\|チアミン]]欠乏症の治療に用いられる医薬品およびビタミン剤である。化学的には[[disulfide/ja\|ジスルフィド]]である。化学的にはチアミンの[[derivative (chemistry)/ja\|誘導体]]であり、[[allithiamine/ja\|アリチアミン]]と構造が似ている。
	'''~~Fursultiamine~~''' ([[International Nonproprietary Name\|INN]]~~; chemical name~~ '''~~thiamine tetrahydrofurfuryl disulfide~~''' or '''TTFD'''~~; brand names~~ '''Adventan''', '''Alinamin-F''', '''Benlipoid''', '''Bevitol Lipophil''', '''Judolor''', '''Lipothiamine'''~~) is a medication and vitamin used to treat~~ [[thiamine]] ~~deficiency. Chemically, it is a~~ [[disulfide]] [[derivative (chemistry)\|~~derivative~~]] ~~of thiamine and is similar in structure to~~ [[allithiamine]].
	~~</div>~~

	<div lang="en" dir="ltr" class="mw-content-ltr">		<div lang="en" dir="ltr" class="mw-content-ltr">

Fire: Created page with " | bioavailability = | metabolism = | elimination_half-life = | excretion ="

2024-04-03T00:41:13Z

Created page with " | bioavailability = | metabolism = | elimination_half-life = | excretion ="

← Older revision		Revision as of 09:41, 3 April 2024
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	<languages />		<languages />
	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	~~{{Short description\|Chemical compound}}~~
	{{Drugbox		{{Drugbox
	\| IUPAC_name = ''N''-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-''N''-<nowiki>{</nowiki>(1''E'')-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide		\| IUPAC_name = ''N''-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-''N''-<nowiki>{</nowiki>(1''E'')-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
	\| image = Fursultiamine.png		\| image = Fursultiamine.png
	\| alt = ~~Skeletal formula of fursultiamine~~		\| alt = フルスルチアミンの骨格式
	\| width = 200		\| width = 200
	\| image2 = Fursultiamine 3D ball.png		\| image2 = Fursultiamine 3D ball.png
	\| alt2 = ~~Ball-and-stick model of the fursultiamine molecule~~		\| alt2 = フルスルチアミン分子のボール＆スティックモデル
	\| width2 = 200		\| width2 = 200
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	<!--Clinical data-->		<!--Clinical data-->
	\| tradename =		\| tradename =
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	\| legal_status = otc		\| legal_status = otc
	\| routes_of_administration = [[Mouth\|Oral]]		\| routes_of_administration = [[Mouth\|Oral]]
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	<!--Pharmacokinetic data-->		<!--Pharmacokinetic data-->
	\| bioavailability =		\| bioavailability =
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	\| elimination_half-life =		\| elimination_half-life =
	\| excretion =		\| excretion =
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	<!--Identifiers-->		<!--Identifiers-->
	\| CAS_number = 804-30-8		\| CAS_number = 804-30-8
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	\| UNII_Ref = {{fdacite\|correct\|FDA}}		\| UNII_Ref = {{fdacite\|correct\|FDA}}
	\| UNII = 05J61265PX		\| UNII = 05J61265PX
	~~</div>~~

	~~<div lang="en" dir="ltr" class="mw-content-ltr">~~
	<!--Chemical data-->		<!--Chemical data-->
	\| C=17 \| H=26 \| N=4 \| O=3 \| S=2		\| C=17 \| H=26 \| N=4 \| O=3 \| S=2
	\| smiles = O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C		\| smiles = O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C
	}}		}}
	~~</div>~~

	<div lang="en" dir="ltr" class="mw-content-ltr">		<div lang="en" dir="ltr" class="mw-content-ltr">

FuzzyBot: Updating to match new version of source page

2024-04-03T00:40:37Z

Updating to match new version of source page

New page

<languages />
<div lang="en" dir="ltr" class="mw-content-ltr">
{{Short description|Chemical compound}}
{{Drugbox
| IUPAC_name = ''N''-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-''N''-<nowiki>{</nowiki>(1''E'')-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
| image = Fursultiamine.png
| alt = Skeletal formula of fursultiamine
| width = 200
| image2 = Fursultiamine 3D ball.png
| alt2 = Ball-and-stick model of the fursultiamine molecule
| width2 = 200
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">

| tradename =
| Drugs.com = {{drugs.com|international|fursultiamine}}
| pregnancy_category =
| legal_status = otc
| routes_of_administration = [[Mouth|Oral]]
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">

| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">

| CAS_number = 804-30-8
| ATC_prefix = None
| ATC_suffix =
| PubChem = 3002119
| ChEMBL = 1740659
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB08966
| ChemSpiderID = 2273321
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 05J61265PX
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">

| C=17 | H=26 | N=4 | O=3 | S=2
| smiles = O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C
}}
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
'''Fursultiamine''' ([[International Nonproprietary Name|INN]]; chemical name '''thiamine tetrahydrofurfuryl disulfide''' or '''TTFD'''; brand names '''Adventan''', '''Alinamin-F''', '''Benlipoid''', '''Bevitol Lipophil''', '''Judolor''', '''Lipothiamine''') is a medication and vitamin used to treat [[thiamine]] deficiency. Chemically, it is a [[disulfide]] [[derivative (chemistry)|derivative]] of thiamine and is similar in structure to [[allithiamine]].
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
It was synthesized in [[Japan]] in the 1960s from [[allithiamine]] for the purpose of developing forms of thiamine with improved [[lipophilicity]] for treating [[Thiamine#Deficiency|vitamin B<sub>1</sub> deficiency]] (i.e., [[beriberi]]), It was subsequently commercialized not only in Japan but also in [[Spain]], [[Austria]], [[Germany]], and the [[United States]].
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
== See also ==
* [[Vitamin B1 analogue|Vitamin B<sub>1</sub> analogue]]
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
== Further reading ==
* {{cite journal | vauthors = Lonsdale D | title = Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent | journal = Medical Science Monitor | volume = 10 | issue = 9 | pages = RA199–203 | date = September 2004 | pmid = 15328496 | url = http://www.medscimonit.com/fulltxt.php?ICID=11763 }}
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
{{Vitamins}}
</div>

<div lang="en" dir="ltr" class="mw-content-ltr">
{{二次利用|date=6 April 2023}}
[[Category:Formamides]]
[[Category:Organic disulfides]]
[[Category:Aminopyrimidines]]
[[Category:Tetrahydrofurans]]
[[Category:Prodrugs]]
[[Category:Thiamine]]
</div>

Fursultiamine/ja - Revision history

Fire: Created page with "Category:Formamides Category:Organic disulfides Category:Aminopyrimidines Category:Tetrahydrofurans Category:Prodrugs Category:Thiamine"

Fire: Created page with "== こちらも参照 == * ビタミンB1類似体"

Fire: Created page with " | tradename = | Drugs.com = {{drugs.com|international|fursultiamine}} | pregnancy_category = | legal_status = otc | routes_of_administration = Oral"

Fire: Created page with " | bioavailability = | metabolism = | elimination_half-life = | excretion ="

FuzzyBot: Updating to match new version of source page

Fire: Created page with "== こちらも参照 == * ビタミンB₁類似体"