Fire: Marked this version for translation

2024-04-03T00:39:54Z

Marked this version for translation

← Older revision		Revision as of 09:39, 3 April 2024
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	<languages />		<languages />
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	{{Short description\|Chemical compound}}		{{Short description\|Chemical compound}}
	{{Drugbox		{{Drugbox
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	<!--Clinical data-->		<!--Clinical data-->
	\| tradename =		\| tradename =
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	\| routes_of_administration = [[Mouth\|Oral]]		\| routes_of_administration = [[Mouth\|Oral]]

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	<!--Pharmacokinetic data-->		<!--Pharmacokinetic data-->
	\| bioavailability =		\| bioavailability =
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	<!--Identifiers-->		<!--Identifiers-->
	\| CAS_number = 804-30-8		\| CAS_number = 804-30-8
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	\| UNII = 05J61265PX		\| UNII = 05J61265PX

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	<!--Chemical data-->		<!--Chemical data-->
	\| C=17 \| H=26 \| N=4 \| O=3 \| S=2		\| C=17 \| H=26 \| N=4 \| O=3 \| S=2
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	}}		}}

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	'''Fursultiamine''' ([[International Nonproprietary Name\|INN]]; chemical name '''thiamine tetrahydrofurfuryl disulfide''' or '''TTFD'''; brand names '''Adventan''', '''Alinamin-F''', '''Benlipoid''', '''Bevitol Lipophil''', '''Judolor''', '''Lipothiamine''') is a medication and vitamin used to treat [[thiamine]] deficiency. Chemically, it is a [[disulfide]] [[derivative (chemistry)\|derivative]] of thiamine and is similar in structure to [[allithiamine]].		'''Fursultiamine''' ([[International Nonproprietary Name\|INN]]; chemical name '''thiamine tetrahydrofurfuryl disulfide''' or '''TTFD'''; brand names '''Adventan''', '''Alinamin-F''', '''Benlipoid''', '''Bevitol Lipophil''', '''Judolor''', '''Lipothiamine''') is a medication and vitamin used to treat [[thiamine]] deficiency. Chemically, it is a [[disulfide]] [[derivative (chemistry)\|derivative]] of thiamine and is similar in structure to [[allithiamine]].

			<!--T:7-->
	It was synthesized in [[Japan]] in the 1960s from [[allithiamine]] for the purpose of developing forms of thiamine with improved [[lipophilicity]] for treating [[Thiamine#Deficiency\|vitamin B<sub>1</sub> deficiency]] (i.e., [[beriberi]]), It was subsequently commercialized not only in Japan but also in [[Spain]], [[Austria]], [[Germany]], and the [[United States]].		It was synthesized in [[Japan]] in the 1960s from [[allithiamine]] for the purpose of developing forms of thiamine with improved [[lipophilicity]] for treating [[Thiamine#Deficiency\|vitamin B<sub>1</sub> deficiency]] (i.e., [[beriberi]]), It was subsequently commercialized not only in Japan but also in [[Spain]], [[Austria]], [[Germany]], and the [[United States]].

	== See also ==		== See also == <!--T:8-->
	* [[Vitamin B1 analogue\|Vitamin B<sub>1</sub> analogue]]		* [[Vitamin B1 analogue\|Vitamin B<sub>1</sub> analogue]]

	== Further reading ==		== Further reading == <!--T:9-->
	* {{cite journal \| vauthors = Lonsdale D \| title = Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent \| journal = Medical Science Monitor \| volume = 10 \| issue = 9 \| pages = RA199–203 \| date = September 2004 \| pmid = 15328496 \| url = http://www.medscimonit.com/fulltxt.php?ICID=11763 }}		* {{cite journal \| vauthors = Lonsdale D \| title = Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent \| journal = Medical Science Monitor \| volume = 10 \| issue = 9 \| pages = RA199–203 \| date = September 2004 \| pmid = 15328496 \| url = http://www.medscimonit.com/fulltxt.php?ICID=11763 }}

			<!--T:10-->
	{{Vitamins}}		{{Vitamins}}

			<!--T:11-->
	{{二次利用\|date=6 April 2023}}		{{二次利用\|date=6 April 2023}}
	[[Category:Formamides]]		[[Category:Formamides]]

Fire: Created page with " {{Short description|Chemical compound}} {{Drugbox | IUPAC_name = ''N''-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-''N''-{(1''E'')-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide | image = Fursultiamine.png | alt = Skeletal formula of fursultiamine | width = 200 | image2 = Fursultiamine 3D ball.png | alt2 = Ball-and-stick model of the fursultiamine molecule | width2 = 200 |..."

2024-04-03T00:36:18Z

Created page with "<languages /> <translate> {{Short description|Chemical compound}} {{Drugbox | IUPAC_name = ''N''-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-''N''-<nowiki>{</nowiki>(1''E'')-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide | image = Fursultiamine.png | alt = Skeletal formula of fursultiamine | width = 200 | image2 = Fursultiamine 3D ball.png | alt2 = Ball-and-stick model of the fursultiamine molecule | width2 = 200  |..."

New page

<languages />
<translate>
{{Short description|Chemical compound}}
{{Drugbox
| IUPAC_name = ''N''-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-''N''-<nowiki>{</nowiki>(1''E'')-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
| image = Fursultiamine.png
| alt = Skeletal formula of fursultiamine
| width = 200
| image2 = Fursultiamine 3D ball.png
| alt2 = Ball-and-stick model of the fursultiamine molecule
| width2 = 200


| tradename =
| Drugs.com = {{drugs.com|international|fursultiamine}}
| pregnancy_category =
| legal_status = otc
| routes_of_administration = [[Mouth|Oral]]


| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =


| CAS_number = 804-30-8
| ATC_prefix = None
| ATC_suffix =
| PubChem = 3002119
| ChEMBL = 1740659
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB08966
| ChemSpiderID = 2273321
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 05J61265PX


| C=17 | H=26 | N=4 | O=3 | S=2
| smiles = O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C
}}

'''Fursultiamine''' ([[International Nonproprietary Name|INN]]; chemical name '''thiamine tetrahydrofurfuryl disulfide''' or '''TTFD'''; brand names '''Adventan''', '''Alinamin-F''', '''Benlipoid''', '''Bevitol Lipophil''', '''Judolor''', '''Lipothiamine''') is a medication and vitamin used to treat [[thiamine]] deficiency. Chemically, it is a [[disulfide]] [[derivative (chemistry)|derivative]] of thiamine and is similar in structure to [[allithiamine]].

It was synthesized in [[Japan]] in the 1960s from [[allithiamine]] for the purpose of developing forms of thiamine with improved [[lipophilicity]] for treating [[Thiamine#Deficiency|vitamin B<sub>1</sub> deficiency]] (i.e., [[beriberi]]), It was subsequently commercialized not only in Japan but also in [[Spain]], [[Austria]], [[Germany]], and the [[United States]].

== See also ==
* [[Vitamin B1 analogue|Vitamin B<sub>1</sub> analogue]]

== Further reading ==
* {{cite journal | vauthors = Lonsdale D | title = Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent | journal = Medical Science Monitor | volume = 10 | issue = 9 | pages = RA199–203 | date = September 2004 | pmid = 15328496 | url = http://www.medscimonit.com/fulltxt.php?ICID=11763 }}

{{Vitamins}}

{{二次利用|date=6 April 2023}}
[[Category:Formamides]]
[[Category:Organic disulfides]]
[[Category:Aminopyrimidines]]
[[Category:Tetrahydrofurans]]
[[Category:Prodrugs]]
[[Category:Thiamine]]
</translate>

Fursultiamine - Revision history

Fire: Marked this version for translation